NIH State-of-the-Science Conference
Preventing Alzheimer’s Disease
and Cognitive Decline
April 26–28, 2010
Bethesda, Maryland
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Final Statement | PDF
Program & Abstracts | PDF
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Evidence Report
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National Institute on Aging
Office of Medical Applications of Research
Co-sponsors
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Center for Complementary and Alternative Medicine
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute of Nursing Research
Office of Dietary Supplements
Partners
Centers for Disease Control and Prevention
Centers for Medicare and Medicaid Services
The Agency for Healthcare Research and Quality and the Centers for Disease Control and Prevention provided additional conference development support.
Monday, April 26, 2010
| 8:30 a.m. | Opening Remarks Richard Hodes, M.D. Director National Institute on Aging National Institutes of Health |
| 8:40 a.m. | Charge to the Panel Jennifer M. Croswell, M.D., M.P.H. Acting Director Office of Medical Applications of Research Office of the Director National Institutes of Health |
| 8:50 a.m. | Conference Overview and Panel Activities Martha L. Daviglus, M.D., Ph.D., M.P.H. Panel and Conference Chairperson Professor of Preventive Medicine and Medicine Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago, Illinois |
| General Overview | |
| 9:00 a.m. | Alzheimer's Disease: Nature of the Public Health Problem Mary Ganguli, M.D., M.P.H. University of Pittsburgh Medical Center Department of Psychiatry Western Psychiatric Institute and Clinic |
| 9:20 a.m. | Alzheimer's Disease: Early Diagnosis Ronald Petersen, M.D., Ph.D. Director, Alzheimer's Disease Research Center Department of Neurology Mayo Clinic College of Medicine |
| 9:40 a.m. | Age-Related Cognitive Decline: Nature of the Problem Marilyn Albert, Ph.D. Professor of Neurology Division of Cognitive Neuroscience Johns Hopkins University School of Medicine |
| 10:00 a.m. | Discussion |
| 10:30 a.m. | Age-Related Cognitive Decline: Measurements of Change Dan Mungas, Ph.D. Adjunct Professor Department of Neurology Director, UC Davis Alzheimer's Disease Center University of California Davis School of Medicine |
| 10:50 a.m. | Pathophysiology of Alzheimer's Disease and Age-Related Cognitive Decline David A. Bennett, M.D. Robert C. Borwell Professor of Neurological Sciences Director, Rush Alzheimer's Disease Center Department of Neurological Sciences Rush Medical Center |
| 11:10 a.m. | Interventions in Animal Models of Alzheimer's Disease Carl Cotman, Ph.D. Professor Institute for Brain Aging and Dementia University of California, Irvine |
| 11:30 a.m. | Discussion |
| 12:00 p.m. | Lunch Panel Executive Session |
| What Factors Are Associated With the Reduction of Risk of Alzheimer's Disease? | |
| and | |
| What Factors Are Associated With the Reduction of Risk of Cognitive Decline in Older Adults? | |
| 1:00 p.m. | Nutritional/Dietary Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Foods Martha Clare Morris, Sc.D. Rush Institute for Healthy Aging Rush Medical Center |
| 1:20 p.m. | Nutritional /Dietary Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Complementary and Alternative Medicine Joseph Quinn, M.D. Assistant Professor Department of Neurology Oregon Health and Science University |
| 1:40 p.m. | Evidence-based Practice Center Presentation I: Methodology of Systematic Review and the Factors Associated With the Reduction of Risk of Alzheimer’s Disease and Cognitive Decline John W. Williams, Jr., M.D., M.H.S. Professor Department of General Internal Medicine Duke University |
| 2:00 p.m. | Discussion |
| 2:30 p.m. | Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Physical Activity Arthur Kramer, Ph.D. Beckman Institute University of Illinois |
| 2:50 p.m. | Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Social Engagement and Leisure Activities Laura Fratiglioni, M.D., Ph.D. Karolinska Institute |
| 3:10 p.m. | Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Cognitive Engagement Yaakov Stern, Ph.D. Professor Department of Aging and Dementia Sergievsky Center Columbia University College of Physicians and Surgeons |
| 3:30 p.m. | Discussion |
| 4:00 p.m. | Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Vascular Factors Charles DeCarli, M.D. Professor of Neurology Department of Neurology Director Alzheimer's Disease Center Imaging of Dementia and Aging (IDeA) Laboratory Center for Neuroscience University of California at Davis |
| 4:20 p.m. | Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Depression Constantine Lyketsos, M.D. Professor of Psychiatry and Behavioral Sciences Chair, Department of Psychiatry Johns Hopkins Bayview Medical Center |
| 4:40 p.m. | Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Sociocultural and Demographic Jennifer Manly, Ph.D. Associate Professor Department of Neurology Sergievsky Center Columbia University College of Physicians and Surgeons |
| 5:00 p.m. | Discussion |
| 5:30 p.m. | Adjournment |
Tuesday, April 27, 2010
| What Are the Therapeutic and Adverse Effects of Interventions to Delay the Onset of Alzheimer's Disease? Are There Differences in Outcomes Among Identifiable Subgroups? | |
| 8:30 a.m. | Clinical Trials for Alzheimer's Disease Paul Aisen, M.D. Professor Department of Neurosciences University of California, San Diego School of Medicine |
| What Are the Therapeutic and Adverse Effects of Interventions to Improve or Maintain Cognitive Ability or Function? Are There Differences in Outcomes Among Identifiable Subgroups? | |
| 8:50 a.m. | Clinical Trials in Cognitive Aging Frederick Unverzagt, Ph.D. Director, Neuropsychology Clinic in Psychiatry Training Director, Clinical Neuropsychology Associate Professor of Psychiatry Department of Psychiatry Indiana University School of Medicine |
| 9:10 a.m. | Evidence-based Practice Center Presentation II: The Therapeutic and Adverse Effects of Interventions To Delay the Onset of Alzheimer’s Disease or To Improve Cognitive Ability, and the Differences Among Identifiable Subgroups James Burke, M.D., Ph.D. |
| 9:30 a.m. | Discussion |
| What Are the Relationships Between the Factors That Affect Alzheimer's Disease and the Factors That Affect Cognitive Decline? | |
| 10:00 a.m. | Evidence-based Practice Center Presentation III: The Relationship Between the Factors That Affect Alzheimer’s Disease and Cognitive Decline| Tracey Holsinger, M.D. |
| 10: 20 a.m. | Factors That Protect Against Alzheimer's Disease and Cognitive Decline David A. Bennett, M.D. Robert C. Borwell Professor of Neurological Sciences Director, Rush Alzheimer's Disease Center Department of Neurological Sciences Rush Medical Center |
| 10:40 a.m. | Commentary: Evidence-based Practice Center Systematic Review Hugh Hendrie, D.Sc., M.B., Ch.B. Professor, Department of Psychiatry Indiana University School of Medicine Center Scientist Indiana University Center for Aging Research Research Scientist Regenstrief Institute, Inc. |
| 11:00 a.m. | Discussion |
| 11:30 a.m. | Adjournment |
Wednesday, April 28, 2010
| 9:00 a.m. | Presentation of the Draft State-of-the-Science Statement |
| 9:30 a.m. | Public Discussion |
| 11:00 a.m. | Adjournment Panel Meets in Executive Session |
| 2:00 p.m. | Press Telebriefing |
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